Article
Non-MPL-W515K/L mutations in myeloproliferative neoplasms: Insights from two case reports and a review of the literature.
Expert review of hematology - 1 Oct 2025
Tønne Nesse Ane Sofie, Gjelberg Hilde Kollsete, Sandnes Miriam, Forthun Rakel Brendsdal, Reikvam Håkon
Abstract excerpt
BACKGROUND: Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs) result from clonal proliferation of hematopoietic stem cells, and include polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). Key driver mutations in the JAK2, CALR, and MPL genes are important for diagnosis and differentiation of triple-negative cases. The MPL gene, particularly exon 10, harbors...
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