Article
CCL2 rs1024611Gene Polymorphism in Philadelphia-Negative Myeloproliferative Neoplasms.
Genes - 10 Mar 2022
Hodeib Hossam, Abd El Hai Dina, Tawfik Mohamed A, Allam Alzahraa A, Selim Amal, Elsawy Abdallah Ahmed, Youssef Amira
Abstract excerpt
Introduction: The onset of the Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs) is caused by acquired somatic mutations in target myeloid genes “driver mutations”. The CCL2 gene is overexpressed by non-Hodgkin lymphomas and multiple solid tumors. Aim of the study: to evaluate the possible association of CCL2 rs1024611 SNP and its expression level and the risk of developing...
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