Article
Detection of MPL exon10 mutations in 103 Chinese patients with JAK2V617F-negative myeloproliferative neoplasms.
Blood cells, molecules & diseases - 15 Jun 2011
Chen Xiuhua, Qi Xiling, Tan Yanhong, Xu Zhifang, Xu Aining, Zhang Linlin, Wang Hongwei
Abstract excerpt
JAK2V617F mutation has been reported in 90% of patients with polycythemia vera (PV) and about 50% of patients with essential thromobocythemia (ET) and primary myelofibrosis (PMF). Recently, acquired mutations in the transmembrane-juxtamembrane region of MPL (MPLW515 mutations) have been reported in approximately 5% of JAK2V617F-negative PMF and about 1% of all cases of ET. MPL is the receptor for thrombopoietin...
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