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JAK2, CALR, and MPL mutation spectrum in Japanese patients with myeloproliferative neoplasms

14 Nov 2014

Abstract excerpt

Recurrent somatic mutations in the JAK2, MPL, and CALR genes have been described in patients diagnosed with Philadelphia-negative myeloproliferative neoplasms (MPN), including polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). These mutations are generally mutually exclusive, and their profiles in different disease entities are diverse. In PV, JAK2 mutations exist in...

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PMID: 25398833
DOI: 10.3324/haematol.2014.115113

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