Article

BAIAP2 (IRSp53) as a Multi-Scale Brain-Disease Gene Across Synaptic Circuits and Neurodevelopment

2026-06-10

Abstract excerpt

Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2), which encodes Insulin Receptor Substrate Protein 53 (IRSp53), has emerged as a brain-disease gene. BAIAP2 involvement in pathogenic CNS disorders is due to its roles in molecular architecture, synaptic signaling, circuit computation, and human neurodevelopmental pathology can be examined within a single mechanistic framework. Unlike many synapt...

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Literature Corpus work: 24e52717-3b9a-5930-91ed-7a1b471702d7
DOI: 10.20944/preprints202606.0872.v1

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