Article
A new mouse allele of glutamate receptor delta 2 with cerebellar atrophy and progressive ataxia.
PloS one - 1 Jan 2014
Miyoshi Yuka, Yoshioka Yoshichika, Suzuki Kinuko, Miyazaki Taisuke, Koura Minako, Saigoh Kazumasa, Kajimura Naoko, Monobe Yoko, Kusunoki Susumu, Matsuda Junichiro, Watanabe Masahiko, Hayasaka Naoto
Abstract excerpt
Spinocerebellar degenerations (SCDs) are a large class of sporadic or hereditary neurodegenerative disorders characterized by progressive motion defects and degenerative changes in the cerebellum and other parts of the CNS. Here we report the identification and establishment from a C57BL/6J mouse colony of a novel mouse line developing spontaneous progressive ataxia, which we refer to as ts3. Frequency of the...
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