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Article

TRAF-3 mRNA splice-deletion variants encode isoforms that induce NF-kappaB activation.

Molecular immunology - 1 Jul 1999

van Eyndhoven W G, Gamper C J, Cho E, Mackus W J, Lederman S

Abstract excerpt

Although TRAF-3 gene products are required for signaling in T-B cell collaboration, full-length TRAF-3 appears to lack signaling function in transient transfection assays that measure NF-kappaB activation. However, the TRAF-3 gene also encodes at least three mRNA splice-deletion variants that predict protein isoforms (delta25aa, delta52aa and delta56aa) with altered zinc (Zn) finger domains and unknown functional...

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Identifiers

PMID: 10509816
DOI: 10.1016/s0161-5890(99)00079-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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