Article
Impairment of MHC class I transcription in a mutant bovine B cell line.
Immunogenetics - 1 Jan 1992
Harms J S, Splitter G A
Abstract excerpt
To better define the regulation and expression of bovine major histocompatibility complex (MHC) antigens, the bovine B lymphoblastoid cell line, BL3, was exposed to gamma-irradiation and surviving cells were immunoselected for MHC class I antigen loss. The resulting class I expression loss variant, BL3.1, was characterized at both the protein and genetic levels to ascertain the nature of the defect....
Topics
- Animals
- B-Lymphocytes
- Blotting, Northern
- Cattle
- Cell Line
- Cell Membrane
- Down-Regulation
- Flow Cytometry
- Gene Expression
- Genes, MHC Class I
- Histocompatibility Antigens Class I
- Mutation