Article
Expression of CD14 corrects the slow response to lipopolysaccharide in the 1B8 mutant of the B cell lymphoma 70Z/3.
Immunogenetics - 1 Jan 1998
Brophy V H, Sibley C H
Abstract excerpt
B cells and macrophages both activate NF-kappaB/Rel in response to lipopolysaccharide (LPS), but differ in sensitivity to LPS and in downstream genes that are activated. CD14 is a high-affinity receptor for LPS found on macrophages, but not B cells. We expressed human CD14 (hCD14) in the mouse B...
Topics
- Amino Acid Sequence
- Animals
- B-Lymphocytes
- Cell Nucleus
- Dose-Response Relationship, Drug
- Gene Expression
- Humans
- Immunoglobulin M
- Immunoglobulin kappa-Chains
- Lipopolysaccharide Receptors
- Lipopolysaccharides
- Lymphoma, B-Cell
- Mice
- Molecular Sequence Data
- Mutation
- NF-kappa B
- Proto-Oncogene Proteins
- Time Factors