Article
Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21.
Human molecular genetics - 15 Jan 2011
Spencer Chris C A, Plagnol Vincent, Strange Amy, Gardner Michelle, Paisan-Ruiz Coro, Band Gavin, Barker Roger A, Bellenguez Celine, Bhatia Kailash, Blackburn Hannah, Blackwell Jennie M, Bramon Elvira, Brown Martin A, Brown Matthew A, Burn David, Casas Juan-Pablo, Chinnery Patrick F, Clarke Carl E, Corvin Aiden, Craddock Nicholas, Deloukas Panos, Edkins Sarah, Evans Jonathan, Freeman Colin, Gray Emma, Hardy John, Hudson Gavin, Hunt Sarah, Jankowski Janusz, Langford Cordelia, Lees Andrew J, Markus Hugh S, Mathew Christopher G, McCarthy Mark I, Morrison Karen E, Palmer Colin N A, Pearson Justin P, Peltonen Leena, Pirinen Matti, Plomin Robert, Potter Simon, Rautanen Anna, Sawcer Stephen J, Su Zhan, Trembath Richard C, Viswanathan Ananth C, Williams Nigel W, Morris Huw R, Donnelly Peter, Wood Nicholas W
Abstract excerpt
We performed a genome-wide association study (GWAS) in 1705 Parkinson's disease (PD) UK patients and 5175 UK controls, the largest sample size so far for a PD GWAS. Replication was attempted in an additional cohort of 1039 French PD cases and 1984 controls for the 27 regions showing the strongest...
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