Article
Fine mapping and resequencing of the PARK16 locus in Parkinson's disease.
Journal of human genetics - 1 Jul 2015
Pihlstrøm Lasse, Rengmark Aina, Bjørnarå Kari Anne, Dizdar Nil, Fardell Camilla, Forsgren Lars, Holmberg Björn, Larsen Jan Petter, Linder Jan, Nissbrandt Hans, Tysnes Ole-Bjørn, Dietrichs Espen, Toft Mathias
Abstract excerpt
The PARK16 locus, spanning five genes on chromosome 1, was among the first genetic regions to show genome-wide association in Parkinson's disease (PD). Subsequent investigations have found variability in PARK16 top-hits and association patterns across populations, and the implicated genes and mechanisms are currently unclear. In the present study, we aimed to explore the contribution of PARK16 variability to PD...
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