Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Discrete change in volatile anesthetic sensitivity in mice with inactivated tandem pore potassium ion channel TRESK.

Anesthesiology - 1 Dec 2010

Chae Yun Jeong, Zhang Jianan, Au Paul, Sabbadini Marta, Xie Guo-Xi, Yost C Spencer

Abstract excerpt

BACKGROUND: We investigated the role of tandem pore potassium ion channel (K2P) TRESK in neurobehavioral function and volatile anesthetic sensitivity in genetically modified mice. METHODS: Exon III of the mouse TRESK gene locus was deleted by homologous recombination using a targeting vector. The genotype of bred mice (wild type, knockout, or heterozygote) was determined using polymerase chain reaction....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anesthetics, Inhalation
Share to Hand Strength

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hindlimb Suspension

Share to Pain Measurement

Share to Postural Balance

Share to Potassium Channels

Share to Pulmonary Alveoli

Share to Reaction Time

Source

Open in PubMed Open full text

Identifiers

PMID: 21042202
DOI: 10.1097/ALN.0b013e3181f90ca5
PMCID: PMC3010361

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Discrete change in volatile anesthetic sensitivity in mice with inactivated tandem pore potassium ion channel TRESK.PMID 21042202Read ↗

Knockout of the gene encoding the K(2P) channel KCNK7 does not alter volatile anesthetic sensitivity.Semantic proximity Read ↗

TRESK two-pore-domain K+ channels constitute a significant component of background potassium currents in murine dorsal root ganglion neurones.Semantic proximity Read ↗

TRESK K <sup>+</sup> Channel Activity Regulates Trigeminal Nociception and HeadacheSemantic proximity Read ↗

Identification and characterization of alternative splice variants of the mouse Trek2/Kcnk10 gene.Semantic proximity Read ↗

Cold hypersensitivity increases with age in mice with sickle cell diseaseSemantic proximity Read ↗

Properties, regulation, pharmacology, and functions of the K₂p channel, TRESK.Semantic proximity Read ↗

A causal role for TRESK loss of function in migraine mechanismsSemantic proximity Read ↗

Functional Expression of TRESK-2, a New Member of the Tandem-pore K+ Channel FamilySemantic proximity Read ↗

Reduced Nav1.6 Sodium Channel Activity in Mice Increases In Vivo Sensitivity to Volatile Anesthetics.Semantic proximity Read ↗

Mutations M287L and Q266I in the glycine receptor α1 subunit change sensitivity to volatile anesthetics in oocytes and neurons, but not the minimal alveolar concentration in knockin mice.Semantic proximity Read ↗

Mice with glycine receptor subunit mutations are both sensitive and resistant to volatile anesthetics.Semantic proximity Read ↗

Nonmigraine-associated TRESK K+ channel variant C110R does not increase the excitability of trigeminal ganglion neurons.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.