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Article

Reduced Nav1.6 Sodium Channel Activity in Mice Increases In Vivo Sensitivity to Volatile Anesthetics.

PloS one - 1 Jan 2015

Pal Dinesh, Jones Julie M, Wisidagamage Stella, Meisler Miriam H, Mashour George A

Abstract excerpt

Nav1.6 is a major voltage-gated sodium channel in the central and peripheral nervous systems. Within neurons, the channel protein is concentrated at the axon initial segment and nodes of Ranvier, where it functions in initiation and propagation of action potentials. We examined the role of Nav1.6 in general anesthesia using two mouse mutants with reduced activity of Nav1.6, Scn8amedJ/medJ and Scn8a9J/9J. The mice...

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Identifiers

PMID: 26252017
DOI: 10.1371/journal.pone.0134960
PMCID: PMC4529172

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