Article
Mice with glycine receptor subunit mutations are both sensitive and resistant to volatile anesthetics.
Anesthesia and analgesia - 1 Sept 2002
Quinlan Joseph J, Ferguson Carolyn, Jester Katherine, Firestone Leonard L, Homanics Gregg E
Abstract excerpt
UNLABELLED: We used two mouse lines with glycine receptor mutations to determine whether glycine receptors might play an important role in anesthetic responses in vivo. Spastic (spA) mutants were slightly more sensitive (P = 0.02) to enflurane in the loss-of-righting reflex assay (50% effective concentration [EC(50)] = 1.17 +/- 0.06 atm for controls versus 0.97 +/- 0.06 atm for spA) but were also substantially...
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