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Article

Knockout of the gene encoding the K(2P) channel KCNK7 does not alter volatile anesthetic sensitivity.

Behavioural brain research - 21 Nov 2008

Yost C Spencer, Oh Irene, Eger Edmond I, Sonner James M

Abstract excerpt

The molecular site of action for volatile anesthetics remains unknown despite many years of study. Members of the K(2P) potassium channel family, whose currents are potentiated by volatile anesthetics have emerged as possible anesthetic targets. In fact, a mouse model in which the gene for TREK-1 (KCNK2) has been inactivated shows resistance to volatile anesthetics. In this study we tested whether inactivation of...

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Topics

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Share to Anesthetics, Inhalation
Share to Dose-Response Relationship, Drug

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Halothane

Share to Isoflurane

Share to Potassium Channels

Share to Pulmonary Alveoli

Share to Sequence Homology, Amino Acid

Share to Shaker Superfamily of Potassium Channels

Source

Open in PubMed Open full text

Identifiers

PMID: 18572259
DOI: 10.1016/j.bbr.2008.05.010
PMCID: PMC2669440

Genes

KCNK7
KCNK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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