Article
Identification and characterization of alternative splice variants of the mouse Trek2/Kcnk10 gene.
Neuroscience - 27 Oct 2011
Mirkovic K, Wickman K
Abstract excerpt
Two-pore domain K(+) (K(2P)) channels underlie leak or background potassium conductances in many cells. The Trek subfamily of K(2P) channels, which includes Trek1/Kcnk2 and Trek2/Kcnk10 and has been implicated in depression, nociception, and cognition, exhibits complex regulation and can modulate cell excitability in response to a wide array of stimuli. While alternative translation initiation and alternative...
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