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Article

Novel application of structural equation modeling to correlation structure analysis of CpG island methylation in colorectal cancer.

The American journal of pathology - 1 Dec 2010

Tanaka Noriko, Huttenhower Curtis, Nosho Katsuhiko, Baba Yoshifumi, Shima Kaori, Quackenbush John, Haigis Kevin M, Giovannucci Edward, Fuchs Charles S, Ogino Shuji

Abstract excerpt

The CpG island methylator phenotype (CIMP-high, CIMP1) is a distinct phenotype associated with microsatellite instability (MSI) and BRAF mutation in colon cancer. Recent evidence suggests the presence of KRAS mutation-associated CIMP subtype (CIMP-low, CIMP2). We used cluster analysis, principal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21037082
DOI: 10.2353/ajpath.2010.100361
PMCID: PMC2993288

Genes

BRAF
KRAS
IGF2
MGMT
RUNX3
SOCS1
CHFR
CRABP1
HIC1
IGFBP3
MLH1
NEUROG1
WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21037082-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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