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Article

Prognostic Value of Methylator Phenotype in Stage III Colon Cancer Treated with Oxaliplatin-based Adjuvant Chemotherapy.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Oct 2018

Gallois Claire, Taieb Julien, Le Corre Delphine, Le Malicot Karine, Tabernero Josep, Mulot Claire, Seitz Jean-François, Aparicio Thomas, Folprecht Gunnar, Lepage Côme, Mini Enrico, Van Laethem Jean-Luc, Emile Jean-François, Laurent-Puig Pierre

Abstract excerpt

Purpose: There are conflicting results concerning the prognostic value of the CpG island methylator phenotype (CIMP) in patients with nonmetastatic colon cancer. We studied this phenotype in stage III colon cancer characterized for mismatch repair (MMR), RAS, and BRAF status, and treated with adjuvant FOLFOX-based regimen.Experimental Design: Tumor samples of 1,907 patients enrolled in the PETACC-8 adjuvant phase...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29921730
DOI: 10.1158/1078-0432.CCR-18-0866

Genes

BRAF
IGF2
NEUROG1
RUNX3
SOCS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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