Article
Persistent Friend virus replication and disease in Apobec3-deficient mice expressing functional B-cell-activating factor receptor.
Journal of virology - 1 Jan 2011
Santiago Mario L, Smith Diana S, Barrett Bradley S, Montano Mauricio, Benitez Robert L, Pelanda Roberta, Hasenkrug Kim J, Greene Warner C
Abstract excerpt
Rfv3 is an autosomal dominant gene that influences the recovery of resistant mice from Friend retrovirus (FV) infection by limiting viremia and promoting a more potent neutralizing antibody response. We previously reported that Rfv3 is encoded by Apobec3, an innate retrovirus restriction factor. However, it was recently suggested that the Rfv3 susceptible phenotype of high viremia at 28 days postinfection (dpi)...
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