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Article

Noninfectious retrovirus particles drive the APOBEC3/Rfv3 dependent neutralizing antibody response.

PLoS pathogens - 1 Oct 2011

Smith Diana S, Guo Kejun, Barrett Bradley S, Heilman Karl J, Evans Leonard H, Hasenkrug Kim J, Greene Warner C, Santiago Mario L

Abstract excerpt

Members of the APOBEC3 family of deoxycytidine deaminases counteract a broad range of retroviruses in vitro through an indirect mechanism that requires virion incorporation and inhibition of reverse transcription and/or hypermutation of minus strand transcripts in the next target cell. The selective advantage to the host of this indirect restriction mechanism remains unclear, but valuable insights may be gained...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21998583
DOI: 10.1371/journal.ppat.1002284
PMCID: PMC3188525

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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