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Article

Fv1 restriction and retrovirus vaccine immunity in Apobec3-deficient 129P2 mice.

PloS one - 1 Jan 2013

Halemano Kalani, Barrett Bradley S, Li Sam X, Harper Michael S, Smith Diana S, Heilman Karl J, Santiago Mario L

Abstract excerpt

Understanding the host genetics of the immune response in retrovirus infection models could provide insights for basic HIV vaccine discovery. In Friend retrovirus (FV) infection of mice, Fv1 differentially inhibits N-tropic versus B-tropic FV infection by mediating a capsid-dependent post-entry block, Fv2 susceptibility governs splenomegaly induction, and Rfv3 resistance primes a stronger neutralizing antibody...

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Identifiers

PMID: 23533681
DOI: 10.1371/journal.pone.0060500
PMCID: PMC3606284

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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