Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The tumor-associated EpCAM regulates morphogenetic movements through intracellular signaling.

The Journal of cell biology - 1 Nov 2010

Maghzal Nadim, Vogt Emily, Reintsch Wolfgang, Fraser James S, Fagotto François

Abstract excerpt

Epithelial cell adhesion molecule (EpCAM) is best known as a tumor-associated protein highly expressed in carcinomas. The function of this cell surface protein during embryonic development and its potential role in cancer are still poorly understood. We identified EpCAM in a gain-of-function screen for inducers of abnormal tissue mixing during gastrulation. Elevated EpCAM levels in either the ectoderm or the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Morphogenesis
Share to Antigens, Neoplasm
Share to Cell Adhesion Molecules

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelial Cell Adhesion Molecule

Share to Epithelial Cells

Share to Intracellular Space

Share to Protein Kinase C

Share to Xenopus

Source

Open in PubMed Open full text

Identifiers

PMID: 20974811
DOI: 10.1083/jcb.201004074
PMCID: PMC3003323

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The tumor-associated EpCAM regulates morphogenetic movements through intracellular signaling.PMID 20974811Read ↗

EpCAM in carcinogenesis: the good, the bad or the uglySemantic proximity Read ↗

Functional Implications of the Dynamic Regulation of EpCAM during Epithelial-to-Mesenchymal TransitionSemantic proximity Read ↗

The Emerging Role of EpCAM in Cancer and Stem Cell SignalingSemantic proximity Read ↗

Revisiting the Roles of Pro-Metastatic EpCAM in CancerSemantic proximity Read ↗

The role of EpCAM in physiology and pathology of the epithelium.Semantic proximity Read ↗

Abnormal placental development and early embryonic lethality in EpCAM-null mice.Semantic proximity Read ↗

Epithelial cell adhesion molecule regulation is associated with the maintenance of the undifferentiated phenotype of human embryonic stem cells.Semantic proximity Read ↗

EpCAM and its potential role in tumor-initiating cellsSemantic proximity Read ↗

Serines in the Intracellular Tail of Podoplanin (PDPN) Regulate Cell MotilitySemantic proximity Read ↗

Intracellular domain of epithelial cell adhesion molecule induces Wnt receptor transcription to promote colorectal cancer progressionSemantic proximity Read ↗

Functions of EpCAM in physiological processes and diseases (Review)Semantic proximity Read ↗

EpCAM overexpression prolongs proliferative capacity of primary human breast epithelial cells and supports hyperplastic growthSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.