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Article

EpCAM and its potential role in tumor-initiating cells

1 Jan 2012

Abstract excerpt

Epithelial cell adhesion molecule EpCAM is expressed on a subset of normal epithelia and overexpressed on malignant cells from a variety of different tumor entities. This overexpression is even more pronounced on so-called tumor-initiating cells (TICs) of many carcinomas. Taking this rather ubiquitous expression of EpCAM in carcinomas and TICs into account, the question arises how EpCAM can serve as a reliable...

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PMID: 22647938
DOI: 10.4161/cam.18953

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