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Functional Implications of the Dynamic Regulation of EpCAM during Epithelial-to-Mesenchymal Transition

29 Jun 2021

Abstract excerpt

Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein expressed in epithelial tissues. EpCAM forms intercellular, homophilic adhesions, modulates epithelial junctional protein complex formation, and promotes epithelial tissue homeostasis. EpCAM is a target of molecular therapies and plays a prominent role in tumor biology. In this review, we focus on the dynamic regulation of EpCAM expression...

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PMID: 34209658
DOI: 10.3390/biom11070956

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