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Article

The Emerging Role of EpCAM in Cancer and Stem Cell Signaling

8 Jul 2009

Abstract excerpt

Initially discovered as a dominant antigen on colon carcinomas, the epithelial cell adhesion molecule (EpCAM) was considered a mere cell adhesion molecule and reliable surface-binding site for therapeutic antibodies. Recent findings can better explain the relevance of EpCAM's high-level expression on human cancers and cancer propagating cells, and its negative prognostic potential for survival of patients with...

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PMID: 19584271
DOI: 10.1158/0008-5472.can-09-0654

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