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Revisiting the Roles of Pro-Metastatic EpCAM in Cancer

7 Feb 2020

Abstract excerpt

Epithelial cell adhesion molecule (EpCAM) is a cell surface protein that was discovered as a tumour marker of epithelial origins nearly four decades ago. EpCAM is expressed at basal levels in the basolateral membrane of normal epithelial cells. However, EpCAM expression is upregulated in solid epithelial cancers and stem cells. EpCAM can also be found in disseminated tumour cells and circulating tumour cells....

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PMID: 32046162
DOI: 10.3390/biom10020255

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