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Article

Benzbromarone pharmacokinetics and pharmacodynamics in different cytochrome P450 2C9 genotypes.

Drug metabolism and pharmacokinetics - 1 Jan 2010

Uchida Shinya, Shimada Kayoko, Misaka Shingen, Imai Hiromitsu, Katoh Yasuhiro, Inui Naoki, Takeuchi Kazuhiko, Ishizaki Takashi, Yamada Shizuo, Ohashi Kyoichi, Namiki Noriyuki, Watanabe Hiroshi

Abstract excerpt

Benzbromarone is a uricosuric drug and has been shown to be metabolized predominantly by cytochrome P450(CYP)2C9 in vitro findings. This study aims to investigate the influence of the CYP2C9 genotype on plasma levels of benzbromarone and 6-hydroxybenzbromarone, as well as uric acid lowering effects. A single oral dose pharmacokinetic and pharmacodynamic trial of benzbromarone (100 mg) was performed in 20 healthy...

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PMID: 20962433
DOI: 10.2133/dmpk.dmpk-10-nt-040

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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