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Article

Evaluation of the relationship between polymorphisms in CYP2C8 and CYP2C9 and the pharmacokinetics of celecoxib.

Journal of clinical pharmacology - 1 Dec 2013

Prieto-Pérez Rocío, Ochoa Dolores, Cabaleiro Teresa, Román Manuel, Sánchez-Rojas Sergio Daniel, Talegón María, Abad-Santos Francisco

Abstract excerpt

Celecoxib is metabolized by enzymes of the cytochrome P450 (CYP450) superfamily, mainly CYP2C9 and CYP3A4. Polymorphisms in the CYP2C9 gene have been associated with decreased enzyme activity and alteration of celecoxib pharmacokinetic parameters. However, literature reports are limited, and some results are contradictory. We enrolled 24 healthy volunteers in a single-dose replicated crossover trial with...

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Identifiers

PMID: 23996211
DOI: 10.1002/jcph.169

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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