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Article

CYP2C9 genotype-dependent effects on in vitro drug-drug interactions: switching of benzbromarone effect from inhibition to activation in the CYP2C9.3 variant.

Molecular pharmacology - 1 Sept 2005

Hummel Matthew A, Locuson Charles W, Gannett Peter M, Rock Dan A, Mosher Carrie M, Rettie Allan E, Tracy Timothy S

Abstract excerpt

The CYP2C9.3 variant exhibits marked decreases in substrate turnover compared with the wild-type enzyme, but little is known regarding the effect this variant form may have on the occurrence of drug-drug interactions. To examine this possibility, the effect of the potent CYP2C9 inhibitor, benzbro...

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Source

Identifiers

PMID: 15955872
DOI: 10.1124/mol.105.013763

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15955872-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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