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Article

Frequency of CYP2C9 polymorphisms in Polynesian people and potential relevance to management of gout with benzbromarone.

Joint bone spine - 1 Mar 2014

Roberts Rebecca L, Wallace Mary C, Wright Daniel F B, Cadzow Murray, Dalbeth Nicola, Jones Peter B, Stamp Lisa K, Harrison Andrew A, Black Michael A, Merriman Tony R

Abstract excerpt

OBJECTIVES: Gout is a major health problem in Polynesians and allopurinol, the drug of choice for the management gout, appears to be less effective in Polynesian patients. The uricosuric drug benzbromarone is an alternative treatment but CYP2C9 poor metabolisers (PMs) may be at a heightened risk of benzbromarone-induced hepatotoxicity. The objectives of this study were to determine the frequency of the PM alleles...

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Identifiers

PMID: 23932726
DOI: 10.1016/j.jbspin.2013.07.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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