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Article

Clinical consequences of cytochrome P450 2C9 polymorphisms.

Clinical pharmacology and therapeutics - 1 Jan 2005

Kirchheiner Julia, Brockmöller Jürgen

Abstract excerpt

The gene coding for the cytochrome P450 (CYP) enzyme 2C9 (CYP2C9) carries numerous inherited polymorphisms. Those coding for R144C (*2) and I359L (*3) amino acid substitutions have both significant functional effects and appreciable high population frequencies, and their in vivo consequences have been studied in humans with regard to drug metabolism. This review summarizes present knowledge about the...

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Identifiers

PMID: 15637526
DOI: 10.1016/j.clpt.2004.08.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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