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Article

IKKβ is an IRF5 kinase that instigates inflammation.

Proceedings of the National Academy of Sciences of the United States of America - 9 Dec 2014

Ren Junyao, Chen Xiang, Chen Zhijian J

Abstract excerpt

The transcription factor interferon regulatory factor 5 (IRF5) is essential for the induction of inflammatory cytokines, but the mechanism by which IRF5 is activated is not well understood. Here we present evidence that the kinase IKKβ phosphorylates and activates IRF5 in response to stimulation...

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Identifiers

PMID: 25326420
DOI: 10.1073/pnas.1418516111
PMCID: PMC4267374

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25326420-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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