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Article

Mechanism of endogenous regulation of the type I interferon response by suppressor of IκB kinase epsilon (SIKE), a novel substrate of TANK-binding kinase 1 (TBK1).

The Journal of biological chemistry - 21 Jun 2013

Marion James D, Roberts Charlotte F, Call R Jason, Forbes Jonathan L, Nelson Kristina T, Bell J Ellis, Bell Jessica K

Abstract excerpt

TANK-binding kinase 1 (TBK1) serves as a key convergence point in multiple innate immune signaling pathways. In response to receptor-mediated pathogen detection, TBK1 phosphorylation promotes production of pro-inflammatory cytokines and type I interferons. Increasingly, TBK1 dysregulation has been linked to autoimmune disorders and cancers, heightening the need to understand the regulatory controls of TBK1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

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Source

Open in PubMed Open full text

Identifiers

PMID: 23649622
DOI: 10.1074/jbc.M112.440859
PMCID: PMC3690000

Genes

TBK1
TANK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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