Article
Derived (mutated)-types of TRPV6 channels elicit greater Ca²+ influx into the cells than ancestral-types of TRPV6: evidence from Xenopus oocytes and mammalian cell expression system.
Journal of pharmacological sciences - 1 Jan 2010
Sudo Yuka, Matsuo Kiyotaka, Tetsuo Tomoyuki, Tsutsumi Satoshi, Ohkura Masamichi, Nakai Junichi, Uezono Yasuhito
Abstract excerpt
The frequency of the allele containing three derived nonsynonymous SNPs (157C, 378M, 681M) of the gene encoding calcium permeable TRPV6 channels expressed in the intestine has been increased by positive selection in non-African populations. To understand the nature of these SNPs, we compared the properties of Ca²+ influx of ancestral (in African populations) and derived-TRPV6 (in non-African populations) channels...
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