Article
Mutations in calmodulin-binding domains of TRPV4/6 channels confer invasive properties to colon adenocarcinoma cells.
Channels (Austin, Tex.) - 1 Dec 2020
Arbabian Atousa, Iftinca Mircea, Altier Christophe, Singh Param Priya, Isambert Hervé, Coscoy Sylvie
Abstract excerpt
Transient receptor potential (TRP) channels form a family of polymodal cation channels gated by thermal, mechanical, or chemical stimuli, with many of them involved in the control of proliferation, apoptosis, or cell cycle. From an evolutionary point of view, TRP family is characterized by high conservation of duplicated genes originating from whole-genome duplication at the onset of vertebrates. The conservation...
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