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Article

Parallel selection on TRPV6 in human populations.

PloS one - 27 Feb 2008

Hughes David A, Tang Kun, Strotmann Rainer, Schöneberg Torsten, Prenen Jean, Nilius Bernd, Stoneking Mark

Abstract excerpt

We identified and examined a candidate gene for local directional selection in Europeans, TRPV6, and conclude that selection has acted on standing genetic variation at this locus, creating parallel soft sweep events in humans. A novel modification of the extended haplotype homozygosity (EHH) test was utilized, which compares EHH for a single allele across populations, to investigate the signature of selection at...

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Share to Amino Acid Substitution
Share to Calcium Channels
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18301763
DOI: 10.1371/journal.pone.0001686
PMCID: PMC2246018

Genes

TRPV6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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