Structure-function analyses of human TRPV6 ancestral and derived haplotypes.

doi:10.1016/j.str.2024.10.018

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Article

Structure-function analyses of human TRPV6 ancestral and derived haplotypes.

Structure (London, England : 1993) - 2 Jan 2025

Neuberger Arthur, Shalygin Alexey, Trofimov Yury A, Veretenenko Irina I, Nadezhdin Kirill D, Krylov Nikolay A, Gudermann Thomas, Efremov Roman G, Chubanov Vladimir, Sobolevsky Alexander I

Abstract excerpt

TRPV6 is a Ca2+ selective channel that mediates calcium uptake in the gut and contributes to the development and progression of human cancers. TRPV6 is represented by the ancestral and derived haplotypes that differ by three non-synonymous polymorphisms, located in the N-terminal ankyrin repeat domain (C157R), S1-S2 extracellular loop (M378V), and C-terminus (M681T). The ancestral and derived haplotypes were...

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PMID: 39500315
DOI: 10.1016/j.str.2024.10.018
PMCID: PMC11698656

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