Article
TRPV6 as a Putative Genomic Susceptibility Locus Influencing Racial Disparities in Cancer.
Cancer prevention research (Philadelphia, Pa.) - 1 May 2020
Francis-Lyon Patricia A, Malik Fahreen, Cheng Xiaoyun, Ghezavati Alireza, Xin Feihan, Cai Rafiki
Abstract excerpt
It is well established that African Americans exhibit higher incidence, higher mortality, and more aggressive forms of some cancers, including those of breast, prostate, colon, stomach, and cervix. Here we examine the ancestral haplotype of the TRPV6 calcium channel as a putative genomic factor in this racial divide. The minor (ancestral) allele frequency is 60% in people of African ancestry, but between 1% and...
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