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PRMT8 Controls the Pluripotency and Mesodermal Fate of Human Embryonic Stem Cells By Enhancing the PI3K/AKT/SOX2 Axis.

Stem cells (Dayton, Ohio) - 1 Sept 2017

Jeong Ho-Chang, Park Soon-Jung, Choi Jong-Jin, Go Young-Hyun, Hong Soon-Ki, Kwon Ok-Seon, Shin Joong-Gon, Kim Rae-Kwon, Lee Mi-Ok, Lee Su-Jae, Shin Hyoung Doo, Moon Sung-Hwan, Cha Hyuk-Jin

Abstract excerpt

Basic fibroblast growth factor (bFGF) supplementation is critical to maintain the pluripotency of human pluripotent stem cells (hPSCs) through activation of PI3K/AKT, rather than MEK/ERK pathway. Thus, elaborate molecular mechanisms that preserve PI3K/AKT signaling upon bFGF stimulation may exist in hPSCs. Protein arginine methyltransferase 8 (PRMT8) was expressed and then its level gradually decreased during...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28543863
DOI: 10.1002/stem.2642

Genes

PRMT8
SOX2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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