Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phosphorylation regulates human OCT4.

Proceedings of the National Academy of Sciences of the United States of America - 8 May 2012

Brumbaugh Justin, Hou Zhonggang, Russell Jason D, Howden Sara E, Yu Pengzhi, Ledvina Aaron R, Coon Joshua J, Thomson James A

Abstract excerpt

The transcription factor OCT4 is fundamental to maintaining pluripotency and self-renewal. To better understand protein-level regulation of OCT4, we applied liquid chromatography-MS to identify 14 localized sites of phosphorylation, 11 of which were previously unknown. Functional analysis of two sites, T234 and S235, suggested that phosphorylation within the homeobox region of OCT4 negatively regulates its...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Embryonic Stem Cells
Share to Immunoprecipitation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitogen-Activated Protein Kinase 1

Share to Octamer Transcription Factor-3

Share to Serine

Share to SOXB1 Transcription Factors

Share to Threonine

Share to Transcriptional Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 22474382
DOI: 10.1073/pnas.1203874109
PMCID: PMC3358887

Genes

SALL4
SOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phosphorylation regulates human OCT4.PMID 22474382Read ↗

An expanded Oct4 interaction network: implications for stem cell biology, development, and disease.Semantic proximity Read ↗

Structural characterization of stem cell factors Oct4, Sox2, Nanog and Esrrb disordered domains, and a method to identify their phospho-dependent binding partnersSemantic proximity Read ↗

Phosphorylation of Sox2 Cooperates in Reprogramming to Pluripotent Stem CellsSemantic proximity Read ↗

Regulation of Oct1/Pou2f1 transcription activity by O-GlcNAcylation.Semantic proximity Read ↗

Phosphorylation stabilizes Nanog by promoting its interaction with Pin1.Semantic proximity Read ↗

O-GlcNAc regulates pluripotency and reprogramming by directly acting on core components of the pluripotency network.Semantic proximity Read ↗

Initial OCT4 engagement with the somatic proteome during reprogramming to iPSCSemantic proximity Read ↗

Quantitative Analysis of Human Pluripotency and Neural Specification by In-Depth (Phospho)Proteomic ProfilingSemantic proximity Read ↗

An Oct4-centered protein interaction network in embryonic stem cells.Semantic proximity Read ↗

Oct4 redox sensitivity potentiates reprogramming and differentiationSemantic proximity Read ↗

A general mechanism for transcription regulation by Oct1 and Oct4 in response to genotoxic and oxidative stress.Semantic proximity Read ↗

Inducible expression of Oct-3/4 reveals synergy with Klf4 in targeting Cyclin A2 to enhance proliferation during early reprogrammingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.