Article
OCT4 and PAX6 determine the dual function of SOX2 in human ESCs as a key pluripotent or neural factor
18 Apr 2019
Abstract excerpt
BACKGROUND: Sox2 is a well-established pluripotent transcription factor that plays an essential role in establishing and maintaining pluripotent stem cells (PSCs). It is also thought to be a linage specifier that governs PSC neural lineage specification upon their exiting the pluripotent state. However, the exact role of SOX2 in human PSCs was still not fully understood. In this study, we studied the role of SOX2...