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Article

Phosphorylation of TFCP2L1 by CDK1 is required for stem cell pluripotency and bladder carcinogenesis

11 Nov 2019

Abstract excerpt

Molecular programs involved in embryogenesis are frequently upregulated in oncogenic dedifferentiation and metastasis. However, their precise roles and regulatory mechanisms remain elusive. Here, we showed that CDK1 phosphorylation of TFCP2L1, a pluripotency-associated transcription factor, orchestrated pluripotency and cell-cycling in embryonic stem cells (ESCs) and was aberrantly activated in aggressive bladder...

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Share to Bladder and Urothelial Cancer Treatments
Share to Epigenetics and DNA Methylation
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PMID: 31709755
DOI: 10.15252/emmm.201910880

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