Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

No association of TPH1 218A/C polymorphism with treatment response and intolerance to SSRIs in Japanese patients with major depression.

Neuropsychobiology - 1 Jan 2007

Kato Masaki, Wakeno Masataka, Okugawa Gaku, Fukuda Tsuyoshi, Azuma Junichi, Kinoshita Toshihiko, Serretti Alessandro

Abstract excerpt

BACKGROUND: Variability in antidepressant response is due to genetic and environmental factors. Since SSRIs exert their activity enhancing the serotonin turnover, genes coding for proteins of the serotonin system are key candidates for a possible genetic influence with response to SSRIs. Therefore tryptophan hydroxylase (TPH), the rate-limiting enzyme in the biosynthesis of serotonin in the raphe nuclei could be...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Analysis of Variance
Share to Antidepressive Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Depressive Disorder, Major

Share to Multivariate Analysis

Share to Selective Serotonin Reuptake Inhibitors

Share to Severity of Illness Index

Share to Tryptophan Hydroxylase

Source

Identifiers

PMID: 18332644
DOI: 10.1159/000119734

Genes

TPH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

No association of TPH1 218A/C polymorphism with treatment response and intolerance to SSRIs in Japanese patients with major depression.PMID 18332644Read ↗

TPH1 is associated with major depressive disorder but not with SSRI/SNRI response in Taiwanese patients.Semantic proximity Read ↗

TPH1 218A/C polymorphism is associated with major depressive disorder and its treatment response.Semantic proximity Read ↗

Association between the tryptophan hydroxylase-1 gene A218C polymorphism and citalopram antidepressant response in a Korean population.Semantic proximity Read ↗

No association between the tryptophan hydroxylase gene polymorphism and major depressive disorders and antidepressant response in a Korean population.Semantic proximity Read ↗

Tryptophan hydroxylase 2 gene is associated with major depression and antidepressant treatment response.Semantic proximity Read ↗

Association between the TPH1 A218C polymorphism and antidepressant response: evidence from an updated ethnicity, antidepressant-specific, and ethnicity-antidepressant interaction meta-analysis.Semantic proximity Read ↗

[Association of TPH2 gene polymorphism with response to antidepressant treatment among ethnic Han Chinese population].Semantic proximity Read ↗

TPH2 polymorphisms may modify clinical picture in treatment-resistant depression.Semantic proximity Read ↗

5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression.Semantic proximity Read ↗

Common genetic variations in human brain-specific tryptophan hydroxylase-2 and response to antidepressant treatment.Semantic proximity Read ↗

HTR2A is associated with SSRI response in major depressive disorder in a Japanese cohort.Semantic proximity Read ↗

Association between single nucleotide polymorphisms of TPH1 and TPH2 genes, and depressive disorders.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.