Article
Phylogenetic approach reveals that virus genotype largely determines HIV set-point viral load.
PLoS pathogens - 30 Sept 2010
Alizon Samuel, von Wyl Viktor, Stadler Tanja, Kouyos Roger D, Yerly Sabine, Hirschel Bernard, Böni Jürg, Shah Cyril, Klimkait Thomas, Furrer Hansjakob, Rauch Andri, Vernazza Pietro L, Bernasconi Enos, Battegay Manuel, Bürgisser Philippe, Telenti Amalio, Günthard Huldrych F, Bonhoeffer Sebastian
Abstract excerpt
HIV virulence, i.e. the time of progression to AIDS, varies greatly among patients. As for other rapidly evolving pathogens of humans, it is difficult to know if this variance is controlled by the genotype of the host or that of the virus because the transmission chain is usually unknown. We apply the phylogenetic comparative approach (PCA) to estimate the heritability of a trait from one infection to the next,...
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