Viral genetic variation accounts for a third of variability in HIV-1 set-point viral load in Europe.

doi:10.1371/journal.pbio.2001855

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Article

Viral genetic variation accounts for a third of variability in HIV-1 set-point viral load in Europe.

PLoS biology - 1 Jun 2017

Blanquart François, Wymant Chris, Cornelissen Marion, Gall Astrid, Bakker Margreet, Bezemer Daniela, Hall Matthew, Hillebregt Mariska, Ong Swee Hoe, Albert Jan, Bannert Norbert, Fellay Jacques, Fransen Katrien, Gourlay Annabelle J, Grabowski M Kate, Gunsenheimer-Bartmeyer Barbara, Günthard Huldrych F, Kivelä Pia, Kouyos Roger, Laeyendecker Oliver, Liitsola Kirsi, Meyer Laurence, Porter Kholoud, Ristola Matti, van Sighem Ard, Vanham Guido, Berkhout Ben, Kellam Paul, Reiss Peter, Fraser Christophe

Abstract excerpt

HIV-1 set-point viral load-the approximately stable value of viraemia in the first years of chronic infection-is a strong predictor of clinical outcome and is highly variable across infected individuals. To better understand HIV-1 pathogenesis and the evolution of the viral population, we must quantify the heritability of set-point viral load, which is the fraction of variation in this phenotype attributable to...

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PMID: 28604782
DOI: 10.1371/journal.pbio.2001855
PMCID: PMC5467800

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