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Article

How effectively can HIV phylogenies be used to measure heritability?

1 Jan 2013

Abstract excerpt

BACKGROUND AND OBJECTIVES: The severity of HIV-1 infection, measured by set-point viral load (SPVL), is highly variable between individuals. Its heritability between infections quantifies the control the pathogen genotype has over disease severity. Heritability estimates vary widely between studies, but differences in methods make comparison difficult. Phylogenetic comparative analysis offers measures of...

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PMID: 24481201
DOI: 10.1093/emph/eot019

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