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Article

Estimating the Respective Contributions of Human and Viral Genetic Variation to HIV Control.

PLoS computational biology - 1 Feb 2017

Bartha István, McLaren Paul J, Brumme Chanson, Harrigan Richard, Telenti Amalio, Fellay Jacques

Abstract excerpt

We evaluated the fraction of variation in HIV-1 set point viral load attributable to viral or human genetic factors by using joint host/pathogen genetic data from 541 HIV infected individuals. We show that viral genetic diversity explains 29% of the variation in viral load while host factors explain 8.4%. Using a joint model including both host and viral effects, we estimate a total of 30% heritability,...

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Source

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Identifiers

PMID: 28182649
DOI: 10.1371/journal.pcbi.1005339
PMCID: PMC5300119

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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