Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Phylogeny-aware GWAS Framework to Correct for Heritable Pathogen Effects on Infectious Disease Traits.

Molecular biology and evolution - 3 Aug 2022

Nadeau Sarah, Thorball Christian W, Kouyos Roger, Günthard Huldrych F, Böni Jürg, Yerly Sabine, Perreau Matthieu, Klimkait Thomas, Rauch Andri, Hirsch Hans H, Cavassini Matthias, Vernazza Pietro, Bernasconi Enos, Fellay Jacques, Mitov Venelin, Stadler Tanja

Abstract excerpt

Infectious diseases are particularly challenging for genome-wide association studies (GWAS) because genetic effects from two organisms (pathogen and host) can influence a trait. Traditional GWAS assume individual samples are independent observations. However, pathogen effects on a trait can be heritable from donor to recipient in transmission chains. Thus, residuals in GWAS association tests for host genetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Communicable Diseases
Share to Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phenotype

Share to Phylogeny

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait, Heritable

Source

Open in PubMed Open full text

Identifiers

PMID: 35921544
DOI: 10.1093/molbev/msac163
PMCID: PMC9366186

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Phylogeny-aware GWAS Framework to Correct for Heritable Pathogen Effects on Infectious Disease Traits.PMID 35921544Read ↗

A phylogeny-aware GWAS framework to correct for heritable pathogen effects on infectious disease traitsSemantic proximity Read ↗

The Heritability of Pathogen Traits - Definitions and EstimatorsSemantic proximity Read ↗

Phylogenetic approach reveals that virus genotype largely determines HIV set-point viral load.Semantic proximity Read ↗

The quantitative genetics of the prevalence of infectious diseases: hidden genetic variation due to Indirect Genetic Effects dominates heritable variation and response to selectionSemantic proximity Read ↗

Dissecting HIV Virulence: Heritability of Setpoint Viral Load, CD4+ T Cell Decline and Per-Parasite PathogenicitySemantic proximity Read ↗

A phylogenetic method to perform genome-wide association studies in microbesSemantic proximity Read ↗

How effectively can HIV phylogenies be used to measure heritability?Semantic proximity Read ↗

MutaPhy: A clade-based framework to detect genotype-phenotype associations on phylogenetic treesSemantic proximity Read ↗

The quantitative genetics of the prevalence of infectious diseases: hidden genetic variation due to indirect genetic effects dominates heritable variation and response to selection.Semantic proximity Read ↗

Dissecting HIV Virulence: Heritability of Setpoint Viral Load, CD4+ T-Cell Decline, and Per-Parasite Pathogenicity.Semantic proximity Read ↗

A Novel Statistical Model to Estimate Host Genetic Effects Affecting Disease Transmission.Semantic proximity Read ↗

Correcting for population stratification reduces false positive and false negative results in joint analyses of host and pathogen genomesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.