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Article

Regulation of PTEN stability and activity by Plk3.

The Journal of biological chemistry - 17 Dec 2010

Xu Dazhong, Yao Yixin, Jiang Xuejun, Lu Luo, Dai Wei

Abstract excerpt

By studying primary isogenic murine embryonic fibroblasts (MEFs), we have shown that PLK3 null MEFs contain a reduced level of phosphatase and tensin homolog (PTEN) and increased Akt1 activation coupled with decreased GSK3β activation under normoxia and hypoxia. Purified recombinant Plk3, but not a kinase-defective mutant, efficiently phosphorylates PTEN in vitro. Mass spectrometry identifies threonine 366 and...

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Source

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Identifiers

PMID: 20940307
DOI: 10.1074/jbc.M110.166462
PMCID: PMC3000975

Genes

PTEN
PDK1
PLK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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