Essential role of AKT-1/protein kinase B alpha in PTEN-controlled tumorigenesis.

Abstract excerpt

PTEN is mutated at high frequency in many primary human cancers and several familial cancer predisposition disorders. Activation of AKT is a common event in tumors in which the PTEN gene has been inactivated. We previously showed that deletion of the murine Pten gene in embryonic stem (ES) cells led to increased phosphatidylinositol triphosphate (PIP(3)) accumulation, enhanced entry into S phase, and better cell...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Enzyme Activation
• Share to Gene Targeting